Table 1.
Comparison of clinical characteristics and ANCA specificity between patients included or excluded, based on the availability of C3 and C4 plasma levels obtained before any immunosuppressive treatment (M/F: male/female; IQR: interquartile ranges).
Table 2.
Clinical characteristics and ANCA specificity of granulomatosis with polyangiitis and microscopic polyangiitis patients, according to low or normal plasma complement levels (absolute values) performed before treatment (M/F: male/female; IQR: interquartile ranges).
Fig 1.
Kaplan-Meier estimate of overall (A), renal (B) and relapse-free (C) survival rates in patients with granulomatosis with polyangiitis or microscopic polyangiitis, according to low or normal plasma complement levels (absolute values) performed before treatment (p = 0.0011, <0.001 and 0.093, respectively).
Fig 2.
Kaplan-Meier estimate of overall (A'), renal (B') and relapse-free (C') survival rates in patients with granulomatosis with polyangiitis or microscopic polyangiitis, according to the low normal or high normal plasma C3 levels (relative values) performed before treatment, based on the median value of C3 levels observed in the whole cohort (p = 0.23, 0.07 and 0.60, respectively).
Table 3.
Clinical characteristics and ANCA specificity of granulomatosis with polyangiitis and microscopic polyangiitis patients, according to the low normal or high normal plasma C3 levels (relative values) performed before treatment, based on the median value of C3 levels observed in the whole cohort (M/F: male/female; IQR: interquartile ranges).
Fig 3.
Kaplan-Meier estimate of overall (A''), renal (B'') and relapse-free (C'') survival rates in patients with granulomatosis with polyangiitis or microscopic polyangiitis, according to the low normal or high normal plasma C4 levels (relative values) performed before treatment, based on the median value of C4 levels observed in the whole cohort (p = 0.83, 0.69 and 0.20, respectively).
Table 4.
Clinical characteristics and ANCA specificity of granulomatosis with polyangiitis and microscopic polyangiitis patients, according to the low normal or high normal plasma C4 levels (relative values) performed before treatment, based on the median value of C4 levels observed in the whole cohort (M/F: male/female; IQR: interquartile ranges).