Table 1.
Participant characteristics and working memory performance.
Table 2.
Change in DTI metrics of white matter microstructure.
Fig 1.
Spatial Span Backward and Digit Span Backward scores with age.
Spaghetti plots of individual participant change in Spatial Span Backward and Digit Span Backward scores with age (years). Females are plotted in red and males in blue. For each measure, an assumption-free general additive mixed model as a function of age was fitted to accurately describe group-level changes across the age range.
Table 3.
MD change in white matter tracts and working memory change.
Table 4.
RD change in white matter tracts and working memory change.
Table 5.
AD change in white matter tracts and working memory change.
Fig 2.
FA or MD and change in visuospatial working memory.
Scatterplots showing linear relationships between change in FA or MD and change in visuospatial working memory. The plots show FA and MD in TOIs, plotted as z-transformed change values. For Spatial Span Backward scores age, sex and interval are regressed out, and for each TOI age, sex, interval and motion at both time points are regressed out. The partial correlation (r) between change in FA and MD in specific white matter tracts and change in Spatial Span Backward scores, controlling for age, sex, interval and motion at both time points are presented in each plot. The color-coded scatterplots represent the color of each specific white matter tract. Color codes refer to: Yellow: Inferior fronto-occipital fasciculus (IFOF), Red: Forceps major (FMaj), Light blue: Inferior longitudinal fasciculus (ILF) and Green: Uncinate fasciculus (UF). R = right.
Fig 3.
RD or AD change in visuospatial working memory.
Scatterplots showing linear relationships between change in RD or AD change in visuospatial working memory in TOIs, plotted as z-transformed change values. For Spatial Span Backward scores age, sex and interval are regressed out, and for each TOI age, sex, interval and motion at both time points are regressed out. The partial correlation (r) between change in RD or AD and change in Spatial Span Backward scores, controlling for age, sex, interval and motion at both time points are presented in each plot. The color-coded scatterplots represent the color of each specific white matter tract. Color codes refer to: Light blue: Inferior longitudinal fasciculus (ILF), Yellow: Inferior fronto-occipital fasciculus (IFOF), Red: Forceps major (FMaj) and Green: Uncinate fasciculus (UF). R = right.