Fig 1.
ROS signaling in bystander cells.
(A) ROS time lapse fluorescence intensity. (B) Inhibition of ROS after the addition of 0.5 Gy ICCM along with ERK inhibitor (PD98059). (C) Increase in production of ROS after the addition of 0.5 Gy ICCM in combination with JNK inhibitor (SP600125).
Fig 2.
NO signaling in bystander cells.
NO signaling in HaCaT cells after the addition of 0.5 Gy ICCM and 0 Gy ICCM.
Fig 3.
Fluorescence intensity levels for ROS and GSH were measured in bystander cells after the addition of 0.005 Gy, 0.05 Gy and 0.5 Gy ICCM.
(A) Fluorescence intensity levels for ROS using CM-H2DCFDA dye in HaCaT cells after the addition of conditioned media. (B) Fluorescence intensity levels for Glutathione using ThiolTrackerTM Violet in HaCaT cells after the addition of conditioned media.
Fig 4.
Luminescence levels indicating caspase activation (A) and fluorescence intensity levels indicating cell viability (B) and cytotoxicity (C) in bystander cells after the addition of 0.005 Gy, 0.05 Gy and 0.5 Gy ICCM.
Table 1.
Viability.
Table 2.
Cytotoxicity.
Table 3.
Caspase activation.