Fig 1.
Patients’ recruitment flowchart.
Fig 2.
Study design.
Fig 3.
Apomorphine/placebo effect on cold pain threshold (seconds) in a non-painful site (hand) (n = 31).
Boxplot representing median, 25th and 75th percentiles for cold pain threshold (sec) in the hand for the two study conditions, measured before (baseline) and after drug administration. The asterisk represents a significant difference only between baseline and test 3 measurements following apomorphine administration. * <0.01.
Table 1.
Apomorphine/placebo effects on experimental cold pain in a non-painful site (hand).
Fig 4.
Apomorphine/placebo effect on cold pain tolerance (seconds) in a non-painful site (hand) (n = 28).
Boxplot representing median, 25th and 75th percentiles for cold pain tolerance (sec) in the hand for the two study conditions, measured before (baseline) and after drug administration. The asterisk represents a significant difference only between baseline and test 3 measurements following apomorphine administration. * <0.01.
Fig 5.
Apomorphine/placebo effect on cold pain tolerance in the painful leg (n = 19).
Boxplot representing median, 25th and 75th percentiles for cold pain tolerance (sec) in the affected leg for the two study conditions, measured before (baseline) and after drug administration. No significant differences between baseline and test 1–3 measurements were detected following apomorphine/placebo administration.
Table 2.
Apomorphine/placebo effects on spontaneous pain and on pain evoked by cold stimulation in the painful leg.
Table 3.
The number of patients who experienced different side effects.