Table 1.
Diagnostic items for US scoring system.
Table 2.
US score system and probability and risk of SS in SS or non-SS patients who are compatible with AECG or ACR criteria.
Fig 1.
Representative US images/scores, ACR/EULAR scores, and integrated ACR/EULAR plus US scores vs. clinical SS diagnosis.
Five patients (A-E) were clinically diagnosed as SS or non-SS by rheumatologists (clinical diagnosis). US grades were calculated as described in the text. ACR/EULAR scores were calculated based on the 5 test (serological test for anti-SS-A antibodies, labial salivary gland biopsy, ocular staining test, and salivary flow test) as previously described [1], except for the salivary flow test, which was performed by Saxon test. Patients were diagnosed as SS or non-SS based on the ACR/EULAR criteria (threshold score ≥4) or on the integrated ACR/EULAR plus US scores (threshold score ≥5, using assigned US score of 3) as described in the text. Patients were also classified into SS or non-SS based on the AECG or ACR classification criteria as previously described [10, 11]. Two patients (C and E) whose results are shown in bold were those with different classification results between the ACR/EULAR criteria and the clinical diagnosis by rheumatologists, but with the same results between the integrated ACR/EULAR plus US criteria and the clinical diagnosis.
Table 3.
Diagnostic ability of combined classification system of 2016 ACR/EULAR and AECG criteria-based US scores for SS in 40 SS and 22 non-SS patientsa.
Table 4.
Diagnostic ability of combined classification system of 2016 ACR/EULAR and AECG criteria-based US scores for primary SS in 23 SS and 20 non-SS patientsa.
Table 5.
Cross-validation of single or combined criteria for SS.
Table 6.
Integrated score system based on the ACR/EULAR and US classifications.