Table 1.
Baseline characteristics of subjects.
Fig 1.
Association between NBL1-Ab level and disease.
Pooled OSA group data were compared with those of patients with ACS and HVs. Significant differences were observed among the three groups using the Kruskal—Wallis test (p < 0.004). Post hoc analysis using the Steel—Dwass test revealed significant differences between both patients with OSA and ACS and the HVs (Fig 1A). Patients with OSA were stratified by OSA severity (Fig 1B) or by having a history of CAD (Fig 1C) and then compared with patients with ACS and HVs. Significant differences were observed in both comparisons using the Kruskal—Wallis test (p < 0.003 and p < 0.001). Post hoc analysis using the Steel—Dwass test revealed significant differences between both patients with severe OSA and OSA patients with CAD versus HVs. Horizontal lines represent medians, boxes represent the 25th and 75th percentiles, whiskers represent the 10th and 90th percentiles and dots represent outliers. ACS, acute coronary syndrome; CAD, coronary artery disease; HV, healthy volunteer; NBL1-Abs, autoantibodies against NBL1; OSA, obstructive sleep apnea; w/o, without.
Fig 2.
Association of NBL1-Ab with clinical parameters in patients with OSA.
Correlations between NBL1-Abs and age (A), gender (B), BMI (C), AHI (D), mean SpO2 (E), arousal index (F), smoking status (G), hypertension (H), diabetes (I), hyperlipidemia (J), CAD (K), and stroke (L) were evaluated. Weak associations were observed between NBL1-Ab levels and age, AHI, mean SpO2 and arousal index. OSA patients with CAD had significantly higher NBL1-Ab levels than OSA patients without CAD. Spearman’s correlation analysis (A, C—F), Mann—Whitney U test (B, H-L) and Kruskal—Wallis test (G) were used. Horizontal lines represent medians, boxes represent the 25th and 75th percentiles, whiskers represent the 10th and 90th percentiles and dots represent outliers. AHI, apnea-hypopnea index; BMI, body mass index; CAD, coronary artery disease; NBL1-Abs, autoantibodies against NBL1; OSA, obstructive sleep apnea.
Table 2.
Logistic regression of the prevalence of CAD in patients with OSA (n = 82; no. of events = 10).
Fig 3.
ROC curve analysis for the predictive value of NBL1-Abs for CAD among all OSA patients.
The area under the curve was 0.739 (95% CI: 0.560–0.863). When the NBL1-Ab cut-off was 27512, the sensitivity of NBL1-Abs for predicting CAD was 70.0% and the specificity was 77.8% (n = 82; no. of events = 10). CAD, coronary artery disease; CI, confidence interval; NBL1-Abs, autoantibodies against NBL1; OSA, obstructive sleep apnea; ROC, receiver operating characteristic.