Fig 1.
Mechanism of action of aspirin and clopidogrel on platelet aggregation and gastric mucosa injury.
Fig 2.
A: Myocardial pathological change in rats (hematoxylin and eosin, 10×). B, C: Comparison of myocardial infarct size using TTC staining, mean ± SD. N = 10. **p<0.01 vs. Sham. #p<0.05, ##p<0.01 vs. Model. +p<0.05 vs. DAPT.
Fig 3.
Effect of treatments on antiplatelets in rats.
A: Platelet aggregation induced by adenosine diphosphate and measured by turbidimetry, mean ± SD. N = 12. **p<0.01 vs. Sham. ##p<0.01 vs. Model. B, C: CD62p measured by flow cytometry, mean ± SD. N = 12. **p<0.01 vs. Sham. ##p<0.01 vs. Model. D: TXB2 and 6-keto-PGF1α levels in rat plasma, measured using a radioimmunoassay, mean ± SD. N = 12. *p<0.05, **p<0.01 vs. Sham; #p<0.05, ##p<0.01 vs. Model; ++p<0.01 vs. DAPT. E: TXB2/6-keto-PGF1α ratio, mean ± SD. N = 12. **p<0.01 vs. Sham; ##p<0.01 vs. Model; ++p<0.01 vs. DAPT.
Fig 4.
Effect of treatments on t-PA and PAI in rats.
Blood was drawn from the abdominal aorta and anticoagulated with sodium citrate. Plasma samples were prepared by centrifugation and analyzed by radioimmunoassay, mean ± SD. N = 12. **p<0.01 vs. Sham. ##p<0.01 vs. Model. +p<0.05 vs. DAPT.
Fig 5.
A: Gastric mucosa ultrastructure imaged by electron microscope, 2,000×, scale bar: 20 μm; 5,000×, scale bar:10 μm. B: Expression of PGE2 and 6-keto-PGFIα in rat gastric mucosa, mean ± SD. N = 12. **p<0.01 vs. Sham. ##p<0.01 vs. Model. ++p<0.01 vs. DAPT. Effect of VEGF levels in rat gastric mucosa, analyzed by immunohistochemistry. mean ± SD. N = 12. *p<0.05, **p<0.01 vs. Sham. #p<0.05, ##p<0.01 vs. Model, +p<0.05 vs. DAPT. C: VEGF expression in rat gastric mucosa, analyzed by immunohistochemistry. Scale bar: 400 μm.
Fig 6.
A: Effect of treatments on COX-1 and COX-2 levels in rat gastric mucosa, analyzed by immunohistochemistry. Scale bar: 400 μm, mean ± SD. N = 12. *p<0.05, **p<0.01 vs. Sham; ##p<0.01 vs. Model; ++p<0.01 vs. DAPT. B: Effect of treatments on the expression of COX-1 and COX-2 in rat gastric mucosa, analyzed by western blotting. Mean ± SD. N = 6. *p<0.05 vs. Sham; #p<0.05, ##p<0.01 vs. Model; ++p<0.01 vs. DAPT.