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Fig 1.

Flowchart of included and excluded trials.

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Table 1.

Characteristics of eligible trials.

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Fig 2.

Funnel plots of meta-analysis.

A: funnel plots for ORR; B: funnel plots for 1-year SR.

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Table 2.

Quality evaluation of included trials.

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Fig 3.

Forest plot of meta-analysis for ORR.

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Fig 4.

Forest plot of meta-analysis for 1-year SR.

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Fig 5.

Forest plot of subgroup analysis for ORR.

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Fig 6.

Forest plot of subgroup analysis for 1-year SR.

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Fig 7.

Forest plot of meta-analysis for anemia (grade 3/4).

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Fig 8.

Forest plot of meta-analysis for nausea/vomiting (grade 3/4).

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Fig 9.

Forest plot of meta-analysis for leukopenia (grade 3/4).

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Fig 10.

Forest plot of meta-analysis for thrombocytopenia (grade 3/4).

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Fig 11.

GRADE system for grading the quality of evidence.

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