Fig 1.
Qualitative renal scintigraphy grading scale for post-KTX Tc-99m MAG3 renal scintigraphy.
Grade 1, a normal renal scintigraphy curve, with fast uptake and excretion. Grade 2, normal uptake with flat excretion curve / plateau phase. Grade 3, rising curve without excretion phase. Grade 4, reduced absolute uptake without excretion phase.
Fig 2.
Quantitative indices for post-KTX renal scintigraphy shown for a normal curve, with the corresponding planar RS images.
Tubular Function Slope (TFS), the linear fit of the curve between 50 and 110 seconds. Corrected tubular extraction rate (cTER), the renal uptake rate for 1 to 2 minutes corrected for body surface. Average upslope, the slope between counts at 20 seconds and counts at 3 minutes. MUC10 resembles the uptake within 10 minutes as a fraction of the injected dose. R20/3, retention to uptake ratio, dividing uptake at 20 minutes by the uptake at 3 minutes.
Table 1.
Patient characteristics grouped according to cohort.
Fig 3.
Kaplan-Meier curves, showing the incidence of delayed graft function within the first month after kidney transplantation (censored for patients with DGF > 30 days, n = 10) for (A) qualitative grading, (B) TFS, (C) cTER, (D) MUC10, and (E) Average upslope. Higher curves for the group of patients with an expected longer duration of delayed graft function and lower curves for the group of patients with in expected shorter duration of delayed graft function, based on quantitative analyses and qualitative grading.
Table 2.
Qualitative and quantitative analysis (sensitivity / specificity / PPV / NPV / ROC) for ≥ 7 days delayed graft function.
Table 3.
Distribution of index values for delayed graft function.