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Fig 1.

Bateson’s cube.

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Table 1.

Study locations, numbers of animals and publication dates.

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Table 2.

Comparison of dates of animal and human studies.

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Table 3.

Reporting (n = studies apart from final column).

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Table 4.

Reported methods of killing animals (n = number of studies).

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Table 5.

Summary results of severity assessment by expert panel.

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Table 6.

Summary of harms.

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Table 7.

Clinical relevance.

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Table 8.

Citation scores.

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Table 9.

Citation scores related to clinical relevance.

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Fig 2.

HBA using Bateson’s cube.

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Fig 2 Expand