Fig 1.
Example of fundus image of a right eye with tracked major superior temporal artery and inferior temporal artery positions on the circle with 1.73 mm radius.
Table 1.
Results of the iteratively applied data selection criteria (see Methods).
Note that the number of excluded eyes is always relative to the number of remaining eyes in the respective previous table row.
Table 2.
Descriptive statistics of the demographics, detailed diagnostics and blood vessel positions including SAA, SVA, IAA and IVA on the four concentric circles with radii of R1: 1.23 mm, R2: 1.73 mm, R3: 2.23 mm and R4: 2.70 mm for mild (MD ≥ -6 dB) and advanced (MD < -6 dB) glaucoma.
MD: mean deviation in decibel (dB); cpRNFLT: circumpapillary retinal nerve fiber layer thickness; OAG: primary or secondary open angle glaucoma; ACG: primary or secondary angle closure glaucoma; MMG: mixed mechanism glaucoma; SAA: superior artery angle; SVA: superior vein angle; IAA: inferior artery angle; IVA: inferior vein angle.
Table 3.
ANOVA results of the impact of blood vessel type, radius, myopia status (myopia: Spherical equivalent < 0 diopter, non-myopia: Spherical equivalent ≥ 0 diopter) and glaucoma stage (mild: MD≥-6 dB, advanced: MD< -6 dB) on the major blood vessel positions in the superior and inferior sectors, respectively.
ANOVA: analysis of variance; MD: mean deviation. Significant results (P<0.05) are marked by asterisks.
Fig 2.
Comparison of mean angular positions of superior BVs between mild and advanced glaucoma on the circle with 1.73 mm radius (i.e., Cirrus standard measurement circle).
As a spatial reference, the Cirrus cpRNFLT norm was added (blue line). Here, the norm for the age of 52 years is shown. The absolute cpRNFLT values decrease with age, but the peak location remains stable.
Fig 3.
Comparison of mean angular position of superior (a) and inferior (b) BVs between mild and advanced glaucoma on the four concentric circles.
Asterisks denote a significant positional difference between mild and advanced glaucoma.
Table 4.
The correlation results between the SAA, SVA, IAA and IVA on the four concentric circles with radii of R1: 1.23 mm, R2: 1.73 mm, R3: 2.23 mm and R4: 2.70 mm and glaucoma diagnostic parameters including MD and cpRNFLT.
SAA: superior artery angle; SVA: superior vein angle; IAA: inferior artery angle; IVA: inferior vein angle; MD: mean deviation; cpRNFLT: circumpapillary retinal nerve fiber layer thickness. Significant results (P<0.05) are marked by asterisks.
Fig 4.
Linear regression from the innermost superior artery positions to the average total deviation in inferior hemifield of the visual field.
Fig 5.
Linear regressions from the angle difference between the innermost and outermost positions of superior artery to (a) the mean deviation and (b) the cpRNFLT.
Table 5.
The correlation results between the differences between the innermost and outermost locations of blood vessels including SAA, SVA, IAA and IVA and glaucoma diagnostic parameters including MD and cpRNFLT.
SAA: superior artery angle; SVA: superior vein angle; IAA: inferior artery angle; IVA: inferior vein angle; MD: mean deviation; cpRNFLT: circumpapillary retinal nerve fiber layer thickness. Significant results (P<0.05) are marked by asterisks.