Fig 1.
Study design: Timing of plasma sampling for BPA assessment.
Baseline pre-dialysis plasma sampling took place after >6 months OL-HDF and prior to the first session with the switch dialyzer. Baseline post-dialysis sampling was obtained immediately after the first session with the switch dialyzer. Sampling was repeated pre- and post-dialysis after 3 months on the switch dialyzer.
Fig 2.
Patient flow chart.
Table 1.
Summary of clinical and biochemical variables.
Fig 3.
Healthy subjects (n = 10); patients on online hemodiafiltration (HDF) (n = 58) and patients on conventional hemodialysis (HD) who were later enrolled in the present study (n = 18) [7]. Data expressed as mean±SD. For HD and OL-HDF, values correspond to baseline predialysis values in the switch studies. At this point, patients had been on HD or OL-HDF for >6 months. * p<0.05; ** p = 0.017.
Fig 4.
Plasma BPA concentration in patients on OL-HDF with polynephron (PN) or polysulfone (PS) membranes.
Pre- and post-dialysis measurements are shown for the first (baseline) and the last (3-month) session after the switch. Prior to the baseline pre-dialysis sample, patients had been on OL-HDF with the opposite membrane for >6 months. Thus, baseline pre-dialysis values represent values corresponding to >6 months OL-HDF with the opposite membrane and were used as baseline values for the switch study, while baseline post-dialysis values were already obtained after the first session with the switch membrane. Data expressed as mean±SD. ** p<0.01. Pre- and Post- refers to pre-dialysis and post-dialysis (OL-HDF) session.