Table 1.
Demographic, clinical and laboratory features of the nine patients with cirrhosis whose biopsy showed large immune complex deposits.
Table 2.
Liver function tests and autoimmune serology results in the nine patients with liver cirrhosis and large glomerular immune complex deposits.
(normal reference values are shown in parenthesis).
Fig 1.
Light microscopy, immunofluorescence, and electron microscopy findings: A-F, Patient 1 and G-I, Patient 6. A) Mild staining for IgG (400x). B) Strong staining for IgA (400x). C) Strong staining for C3 (400x). D) Thickened capillary loops with "wire-loop lesions” (arrow) (Periodic Acid Schiff; 630x). E) and F) Large subendothelial electron dense immune-type deposits on ultrastructural examination (lead citrate and uranyl acetate fixation; 4,000x and 12,000x, respectively). G) Thickened capillary loops (Periodic Acid Schiff; 400x); H) and I). Large subepithelial electron dense immune-type deposits (lead citrate and uranyl acetate fixation; 6000x and 12,000x, respectively).
Fig 2.
Light microscopy, immunofluorescence, and electron microscopy biopsy findings in patient 7.
A) Strong mesangial and capillary loop staining for IgG (400x). B) Strong mesangial and capillary loop staining for IgA (400x). C) Strong mesangial and capillary loop staining for C3 (400x). D) Endocapillary hypercellularity (hematoxylin & eosin; 400x). E) and F) Large bulky mesangial and subendothelial electron dense immune-type deposits on ultrastructural examination (lead citrate and uranyl acetate fixation; 6,000x and 10,000x, respectively).
Table 3.
Kidney biopsy findings in the nine cirrhotic patients with large immune complex deposits.
Table 4.
Cirrhotic patients with kidney biopsy, over a 13-year period (n = 118).
Demographic features and etiology of liver cirrhosis.
Table 5.
Kidney biopsy diagnoses among the 118 patients with cirrhosis, with and without glomerular IgA deposits.
Mean intensity of IgA staining in the 76 patients with IgA deposits are shown.