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Fig 1.

Flow diagram depicting the interventions to be applied in the bundle of care treatment strategy.

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Fig 2.

Data collection sheet.

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Fig 3.

Outcomes pre and post implementation.

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Table 1.

Neonatal mortality and fresh stillbirths at the four hospitals, pre and post bundle of care implementation.

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Table 2.

General characteristics of infants before and after implementation.

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Table 3.

General characteristics and medication use at the four hospitals pre/post implementation.

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Table 4.

General characteristics of infants <35 weeks who survived versus died.

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Table 5.

Outcome of preterm infants expected to 1/2 (partial) or 3/4 (complete) doses of dexamethasone versus no treatment.

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Table 6.

Stepwise logistic regression Analysis for estimating effects of administration of antenatal corticosteroids (ACS), maternal & neonatal antibiotics in combination or singularly for predicting death in preterm infants while controlling for BW, GA, source of admission, mode of delivery and gender.

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Table 7.

General characteristics of Infants 28–30 6/7 weeks vs. 31–34 6/7 weeks who survived versus died.

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Table 8.

Stepwise logistic regression analysis for estimating effects of administration of antenatal corticosteroids (ACS), maternal & neonatal antibiotics in combination or singularly for predicting death in p[reterm infants while controlling for BW, GA, source of admission, mode of delivery and gender for infants 28 to 30 6/7 weeks GA.

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Table 9.

Stepwise logistic regression analysis for estimating effects of administration of antenatal corticosteroids (ACS), maternal & neonatal antibiotics in combination or singularly for predicting death in preterm infants while controlling for BW, GA, source of admission, mode of delivery and gender for infants 31 to 346/7 weeks.

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Fig 4.

Use of medication either singularly or in combination from September 2014 through June 2017.

NM progressively decreased over the comparable time period concurrent with the increased use of medication. (Fig 5).

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Fig 5.

The progressive decrease in mortality from September 2014 through June 2017.

*Comparing years 2014 and 2017—Relative Risk Reduction (RR) and 95% Confidence Interval (CI) 0.658 (0.45–0.96) p = 0.031, ** Comparing years 2015–2017—RR 0.84 (0.73–0.97) p = 0.016. *** Comparing 2016 and 2017 RR 0.91 (0.78–1.06) p = 0.22.

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