Table 1.
Criteria used to infer the reason for TB treatment start amongst persons enrolled in the XTEND trial who had a negative sputum test for TB at enrolment by Xpert or smear microscopy, but who were started on TB treatment during the six month period after enrolment.
Fig 1.
A study profile illustrating the reason for TB treatment start and results of subsequent sputum TB tests amongst persons investigated for TB whose index (enrolment) sputum was negative for TB when tested by Xpert or smear microscopy.
Table 2.
Characteristics of XTEND participants with negative sputum tests for tuberculosis by smear microscopy or Xpert at enrolment into XTEND who were subsequently started on TB treatment during the 6-month follow-up (n = 167).
Sub-groups 1 (empirically treated participants) and sub-group 2 (participants with microbiologically-confirmed TB) are not mutually exclusive as some participants who were started on empiric TB treatment were subsequently found to have microbiologically confirmed TB.
Fig 2.
Consultations en route to TB treatment initiation amongst 167 XTEND participants with negative smear microscopy tests for TB at enrolment, reconstructed from data obtained from patient interviews, case note abstractions and laboratory results and stratified by TB treatment start.
Sequential visits to the same provider are not shown. A: Pathways for entire cohort (n = 167). B: Pathways for persons started on TB treatment empirically (n = 82).
Table 3.
TB investigations, treatment initiation and vital status at 6 months follow up of XTEND participants with negative sputum tests for tuberculosis by smear microscopy or Xpert who were subsequently started on TB treatment during the 6-month follow-up (n = 167).
Sub-groups 1 (empirically treated participants) and sub-group 2 (participants with microbiologically-confirmed TB) are not mutually exclusive as some participants who were started on empiric TB treatment were subsequently found to have microbiologically confirmed TB.