Fig 1.
Glioblastoma multiforme (GBM).
(A) a post-contrast T1-weighted image, (B) an ADC map, (C) a CBV map, (D) a perfusion signal intensity time curve. The ADC (B) and CBV (C) maps show placement of large irregular freehand ROIs within the tumor core and the peritumoral edema as well as small circular ROIs within the big ROIs and in the contralateral normal white matter used as a reference ROI. The perfusion curve (D) shows hemodynamics of contrast agent during the first pass of a bolus through the brain vasculature with an x-axis reflecting time in seconds and y-axis indicating signal intensity. Red transverse line is a baseline.
Table 1.
The values of perfusion and diffusion parameters from the tumor core in GBMs, metastases and PCNSLs with the analysis of variance and multiple post-hoc comparisons among the patient subgroups.
Fig 2.
Glioblastoma multiforme (GBM).
(A) a post-contrast T1-weighted image, (B) an ADC map, (C) a CBV map, (D) perfusion signal intensity time curves. The tumor appears as a small enhancing lesion (white arrows) with a large non-enhancing peritumoral zone mimicking a metastasis. The ADC map (B) shows minimal ADC values similar to normal white matter (0.83 x 10−3 mm2/s within the tumor core and 0.78 x 10−3 mm2/s within the peritumoral region of infiltration). The CBV map (C) shows the hyperperfused tumor core (white arrow, max rCBV = 2.9) and a large area of increased perfusion (yellow arrow, max rCBV = 2.25) within the peritumoral zone indicating neoplastic infiltration which is a feature differentiating GBM from a metastasis surrounded exclusively by a pure vasogenic edema. The perfusion curves (D) present only partial return to the baseline (red transverse line) in both the tumor core (lower curve) and the area of neoplastic infiltration (upper curve).
Fig 3.
(A) a post-contrast T1-weighted image, (B) an ADC map, (C) a CBV map, (D) a perfusion signal intensity time curve. The ADC map (B) shows facilitated diffusion in both the tumor core (min ADC = 1.0 x 10−3 mm2/s) and in the peritumoral zone (min ADC = 1.32 x 10−3 mm2/s). The CBV map (C) shows a highly perfused tumor (max rCBV = 17.9) and no hyperperfusion within the peritumoral zone (max rCBV = 0.78) typical for pure vasogenic edema. The perfusion curve (D) presents partial return to the baseline (red transverse line).
Fig 4.
Primary central nervous system lymphoma (PCNSL).
(A) a post-contrast T1-weighted image, (B) an ADC map, (C) a CBV map, (D) a perfusion signal intensity time curve. The tumor appears as an enhancing solitary lesion with a large peritumoral edema mimicking a metastasis. The ADC map (B) shows restricted diffusion within the tumor core (min ADC = 0.51 x 10−3 mm2/s). The CBV map (C) shows the hypoperfused tumor core (max rCBV = 0.79) with the perfusion curve (D) returning above the baseline (red transverse line) which are typical perfusion characteristics of PCNSL.
Table 2.
The results of ROC analysis for differentiation of PCNSLs from GBMs and metastases as well as GBMs from metastases.
Fig 5.
Receiver operating characteristic (ROC) curve.
ROC analysis for comparisons of perfusion and diffusion parameters from the tumor core (A) which are used for differentiation of PCNSLs from GBMs and metastases as well as from the peritumoral zone (B) used for differentiation of GBMs from metastases. Both graphs A and B show the highest accuracy (the largest area under the curve) for the values of max rCBV.
Table 3.
The values of perfusion and diffusion parameters from the peritumoral zone in GBMs and metastases with the comparisons between the patient subgroups.
Table 4.
Perfusion results of the testing group with the comparison of the suggested and biopsy proven diagnosis.