Fig 1.
CONSORT flowchart.
Fig 2.
Mean concentration profile of metformin administered at 250 mg (Δ) and 1000 mg (●).
(Inlet: log-linear scale; error bars present standard deviation).
Table 1.
Pharmacokinetic parameters after metformin administration.
Table 2.
Results of oral glucose tolerance test (OGTT) before and after administration of metformin.
Fig 3.
Relationships between pharmacokinetic-pharmacodynamic parameters after metformin administration at 250 mg (triangle) and 1000 mg (circle). Reduction in (a) AUG0-3h, (b) Gmax, and (c) PP2 versus AUC0-12h; reduction in (d) AUG0-3h, (e) Gmax, and (f) PP2 versus Cmax.
(The solid lines and dashed lines represent the linear and quadratic models, respectively. The black circle represents data included in the linear regression at high exposure. P-values are from the F-tests, and r2 represents the coefficient of determination.).