Table 1.
Clinical characteristics and lipid profiles of healthy subjects and CETP-D patients.
Fig 1.
Representative chromatographic patterns of normolipidemic subjects and CETP-D patients monitored by Cho (solid line) and TG (dotted line).
(A) a 24-year-old male healthy subject; serum HDL-C: 59mg/dL, LDL-C: 132mg/dL, TG: 83mg/dL. (B) a 52-year-old female healthy subject; serum HDL-C: 69mg/dL, LDL-C: 99mg/dL, TG: 126mg/dL. (C) a 24-year-old male CETP-D patient; serum HDL-C: 138mg/dL, LDL-C: 34mg/dL, TG: 84mg/dL. (D) a 51-year-old female CETP-D patient; serum HDL-C: 197mg/dL, LDL-C: 64mg/dL, TG: 68mg/dL.
Table 2.
Average particle diameters of lipoprotein major subclass of healthy subjects and CETP-D patients.
Fig 2.
Concentrations of A: Cho (mg/dL), B: TG (mg/dL), C: Cho/TG ratio in lipoprotein subclasses between normolipidemic subjects (n = 9, open column) and CETP-D patients (n = 9, closed column).
VL = very large; L = large; M = medium; S = small; VS = very small. All graphs show the mean ± SD. *P<0.05, **P<0.01, ***P<0.001 vs normolipidemic subjects.
Fig 3.
Correction for calculation of the PN of very very large HDL (vvl-HDL) in CETP-D.
(A)The relation between the sum of calculated PNs of CM1-LDL6 according to spherical particle model and serum apoB levels in normolipidemic subjects (open circle) and CETP-D patients (open triangle). (B)After correction for PNs of apoB-containing lipoproteins (actual PNs of CM1-LDL6) in normolipidemic subjects (open circle) and CETP-D patients (open triangle).
Fig 4.
Comparison of particle number of each lipoprotein subclass between normolipidemic subjects (n = 9, open column) and CETP-D patients (n = 9, closed column).
(A) VLDL to LDL fraction, (B) HDL fraction. VVL = very very large; VL = very large; L = large; M = medium; S = small; VS = very small. a PN of very small HDL is assessed only by the PN of HDL6, because HDL7 contains pre-beta-1. HDL for which spherical particle model cannot be applied. All graphs show the mean ± SD. *P<0.05, **P<0.01, *** P<0.001 vs normolipidemic subjects.