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Fig 1.

Trial profile.

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Fig 2.

Risk of a first breakthrough seizure following a period of at least 12 months remission from seizures whilst on treatment.

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Table 1.

Participant demographics for those at risk of a first breakthrough seizure, n (%) unless otherwise stated.

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Table 2.

Multivariable model hazard ratios for time to first breakthrough seizure after a period of 12-month remission whilst on treatment.

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Fig 3.

Risk of a seizure following a breakthrough seizure.

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Table 3.

Participant demographics for those at risk of a seizure, or with a chance of achieving 12-month remission following a first breakthrough seizure, n (%) unless otherwise stated.

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Table 4.

Effect estimates from multivariable models–risk of seizure recurrence following first breakthrough seizure (n = 510) and likelihood of achieving 12-month remission following a breakthrough seizure (n = 510).

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Fig 4.

Chance of achieving 12 month remission following a breakthrough seizure.

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