Fig 1.
Flow chart of literature review.
Table 1.
Characteristics of included studies.
Table 2.
Characteristics of included studies.
Table 3.
Quality assessment of included studies.
Fig 2.
Forest plot of H. pylori eradication rate (intention-to-treat, ITT) with high-dose therapies compared to low-dose therapies.
Fig 3.
Forest plot of H. pylori eradication rate (per-protocol, PP) with high-dose therapies compared to low-dose therapies.
Fig 4.
Forest plot of H. pylori eradication rate with high-dose therapies compared to low-dose therapies in the areas with high vs. low metronidazole resistance.
A. Comparison of the high-dose therapies with low-dose therapies in low metronidazole-resistant areas. B. Comparison of the high-dose therapies with low-dose therapies in high metronidazole-resistant areas.
Fig 5.
Forest plot of H. pylori eradication rate with high-dose therapies compared to low-dose therapies in the metronidazole-resistant vs. susceptible people.
A. Comparison of the high-dose therapies with low-dose therapies in metronidazole-resistant people. B. Comparison of the high-dose therapies with low-dose therapies in metronidazole-susceptible people.
Fig 6.
Forest plot of adherence difference between high-dose therapies and low-dose therapies.
Fig 7.
Forest plot of high-dose therapies vs. low dose-dose therapies in total side effects.