Fig 1.
Mean weekly body weight (mean ± standard deviation) of control group Sprague-Dawley rats during the repeated dose 28-day oral toxicity study.
Male rats were indicated by a green line, and female rats were indicated by a red line.
Fig 2.
The histopathology of organs from the control group Sprague- Dawley rats (200×magnification).
No significant damage was observed in the brain, heart, liver, lung, spleen, kidney, stomach, intestine, testes or ovaries of rats.
Fig 3.
Box and whisker plots show differences in analyte levels of male and female Sprague-Dawley rats on RBC parameters.
Data were depicted as box plots that indicated the median, 25th and 75th percentiles (box), mean (◇), and 1.5 times of interquartile (whiskers). Male rats were indicated by a green line, and female rats were indicated by a red line.
Fig 4.
Box and whisker plots show differences in analyte levels of male and female Sprague-Dawley rats on platelet parameters.
Data were depicted as box plots that indicated the median, 25th and 75th percentiles (box), mean (◇), and 1.5 times of interquartile (whiskers). Male rats were indicated by a green line, and female rats were indicated by a red line.
Fig 5.
Box and whisker plots show differences in analyte levels of male and female Sprague-Dawley rats on WBC parameters.
Data were depicted as box plots that indicated the median, 25th and 75th percentiles (box), mean (◇), and 1.5 times of interquartile (whiskers). Male rats were indicated by a green line, and female rats were indicated by a red line.
Fig 6.
Box and whisker plots show differences in analyte levels of male and female Sprague-Dawley rats on biochemical parameters.
Data were depicted as box plots that indicated the median, 25th and 75th percentiles (box), mean (◇), and 1.5 times of interquartile (whiskers). Male rats were indicated by a green line, and female rats were indicated by a red line.
Table 1.
Sex-specific reference intervals for 24 hematologic analytes in Sprague-Dawley rats.
Table 2.
Sex-specific reference intervals for 9 biochemical analytes in Sprague-Dawley rats.
Table 3.
Reference intervals for key blood variables of different species.