Table 1.
Comparison of findings in original PCR-based sample testing and current microbiome-based analyses.
Fig 1.
Microbiome analysis of throat swabs from 367 subjects (30 controls and 337 sore throat patients).
Shown are the relative proportions of OTUs with higher values represented by Fusobacterium necrophorum and Streptococcus pyogenes. Many positive samples (OTU values less than 0.01) cannot be seen on this scale.
Fig 2.
Correlation between Ct values for all Fn PCR positive samples and the corresponding OTU value for that sample.
Table 2.
Comparison of alpha diversity by five measures in Fn and GAS positive and negative patient groups, and control subjects.
Table 3.
OTU values showing the relative proportion of total Fn or S. pyogenes sequences in which the OTU value in microbiome analysis exceeded 0.1 (i.e. more than 10% of total bacterial 16S sequences obtained) and the corresponding Centor scores among 312 sore throat patients.
Fig 3.
Lower diversity in Fn positive patient samples with higher Centor scores.
Fn positive sore throat patient samples with higher Centor scores (≥ 2) are significantly less diverse than control samples but Fn positive patient samples with lower Centor scores (0 or 1) do not differ significantly from controls in diversity.