Table 1.
Fig 1.
Plasma concentrations of glucose (a), lactate (b), NEFA (c) and insulin (d) in non-exercised mice as well as 6h and 10h after 2h of treadmill running in Controls and IL-6 MKO mice.
Values are mean ± SE (n = 9–10) *: significantly different from non-exercised mice within given genotype (p<0.05), ¤: significantly different from 6h within given genotype (p<0.05), #: significantly different from Control within given time point (p<0.05).
Table 2.
Fig 2.
iWAT SOCS3 mRNA content (a) eWAT SOCS3 mRNA content (b) iWAT UCP1 mRNA content (c) eWAT UCP1 mRNA content (d) in non-exercised mice as well as 6h and 10h after 2h of treadmill running in Control and IL-6 MKO mice.
Values are mean ± SE; (n = 9–10). *: significantly different from non-exercised within given genotype (p<0.05), ¤: significantly different from 6h within given genotype (p<0.05), #: significantly different from Control within given time point (p<0.05).
Fig 3.
iWAT HSLSer660 phosphorylation (a), eWAT HSLSer660 phosphorylation (b), iWAT P38Tyr180/182 phosphorylation (c), eWAT P38Tyr180/182 phosphorylation (d), iWAT GLUT4 protein content (e), iWAT GLUT4 protein content (f), iWAT (g) and eWAT in non-exercised mice as well as 6h or 10h after 2h of treadmill running in d IL-6 MKO and Control mice.
(h) Representative blots of HSL565 phosphorylation, HSL, UCP1 and P38 protein content. Values are mean ± SE; (n = 9–10). *: significantly different from non-exercised within given genotype (p<0.05), ¤: significantly different from 6h within given genotype (p<0.05), #: significantly different from Control within given time point (p<0.05).
Table 3.
Fig 4.
Skeletal muscle glycogen concentration (a), glucose concentration (b), glucose 6 phosphate (G6P) concentration (c) and lactate concentration (d) in non-exercised mice as well as 6h or 10h after 2h of treadmill running in Control and IL-6 MKO mice.
Values are mean ± SE; (n = 9–10). *: significantly different from non-exercised within given genotype (p<0.05), ¤: significantly different from 6h within given genotype (p<0.05).
Fig 5.
PDHa activity (a), PDHSer300 phosphorylation (b) PDK4 protein content (c), ACCSer212 phosphorylation (d) protein content representative blots of, PDHSer232 phosphorylation, PDHSer293 phosphorylation, PDH E1α, AMPKThr172 phosphorylation, AMPK (e) and HKII, GLUT4, LDHa protein content and ACC2 protein content (f).
in non-exercised mice as well as 6h or 10h after 2h of treadmill running in IL-6 MKO and Control mice. Values are mean ± SE;(n = 9–10). *: significantly different from non-exercised within given genotype (p<0.05), ¤: significantly different from 6h within given genotype (p<0.05), #: significantly different from Control within given time point (p<0.05).
Table 4.
Fig 6.
Hepatic glycogen content (a), glucose content (b), lactate content (c) PEPCK mRNA content (d), G6Pase mRNA content (e), SOCS3 mRNA content (f) PEPCK Protein content (g), G6pase protein content (h) representative blots of AMPKThr172 phosphorylation, AMPK protein content, ACC1/2 Ser79/212 phosphorylation, ACC1/2 protein content PDHSer300 phosphorylation, PDH E1α protein content (i) in non-exercised mice as well as 6h or 10h after 2h of treadmill running in Control and IL-6 MKO mice.
Values are mean ± SE; (n = 9–10) *: significantly different from rest within given genotype (p<0.05), ¤: significantly different from 6h within given genotype (p<0.05), #: significantly different from Control within given time point (p<0.05).
Table 5.