Table 1.
Diagnostic criteria for alarm symptoms, blood markers, and fecal calprotectin.
Fig 1.
Abbreviations: IBD: inflammatory bowel disease.
Table 2.
Baseline characteristics of children by referrer and whether endoscopy was performed at baseline.
Table 3.
The various diagnostic models for IBD with the non-imputed and imputed datasets.
Fig 2.
Decision curve for the three models predicting the outcome of IBD in the non-imputed dataset.
Representative interpretation of the decision curve: the purple line representing the alarm symptoms + fecal calprotectin strategy shows a net benefit of 0.16 at a threshold probability of 20%. In this instance, a threshold probability of 20% means that a general practitioner would be willing to refer 5 children to prevent a delay in diagnosis for 1 child with IBD. The net benefit of 0.16 means that this strategy would lead to the referral of 160 per 1000 children at risk, with all referrals having IBD. Abbreviations: CRP: C-reactive protein, FCal: fecal calprotectin.
Table 4.
Reduction in referral rate for further diagnostic work-up per 100 children using different threshold probabilities for the three test strategies.