Table 1.
Baseline demographic characteristics of the participants with and without occult POI.
The mean age, BMI, day of menstrual cycle at the time of blood sampling, and age at menarche were comparable between the participants with and without occult primary ovarian insufficiency (POI). The mean cycle length reported by the participants with occult POI were significantly shorter than those without it. Significantly higher number of participants with occult POI reported a positive family history of premature menopause in their mothers and/or sisters compared to those without occult POI.
Fig 1.
There was an inverse relation between age and AMH.
Quadratic regression model explains this relation better than linear type.
Fig 2.
There was a positive association with AMH level and cycle length on the linear regression analyses.
The association was more significant for the participants with occult POI compared to those without it.
Fig 3.
Repeat AMH measurements in the second visit one month later at early follicular phase were comparable to those at initial assessment in the participants with occult POI.
Table 2.
Menstrual cycle characteristics, and the mean levels of AMH, AFC and FSH of the participants diagnosed with occult POI at initial assessment and one-year follow up.
Serum AMH level and AFC were significantly decreased and FSH level was significantly increased at one-year follow-up of the participants with occult POI compared to their corresponding values at initial assessment. The mean cycle length was significantly shortened and the number of the participants menstruating every 21 days were significantly increased compared to the initial assessment. While none of the participants diagnosed with occult POI had reported any skipped menses in the first assessment, now six of them reported one missed period at one-year follow-up.
Fig 4.
AMH, AFC and cycle length of each participant was reduced at one-year follow-up compared to their baseline values at initial assessment.