Fig 1.
Effect of G-CSF on the development of human ALL in immunocompromised mice.
Mice engrafted with the indicated ALL xenografts (1345R is a repeat of 1345 where initiation of treatment was delayed by 10 days) were treated with G-CSF (125 μg/kg twice daily) for 10 days and culled. (A) The number of ALL cells detected in the indicated tissue is indicated. Each dot represents an individual animal and the mean of the group is indicated by the bar. (B) The mean±SD of the total leukaemia detected in animals is shown. Open bars are control and black bars G-CSF treated. # p<0.05.
Fig 2.
Effect of G-CSF on the in vitro growth of ALL xenograft cells.
(A) Expression of the G-CSFR on ALL cells as determined by flow cytometry. The fine line is the isotype control and the heavy line the G-CSFR specific antibody. (B) The lack of response of ALL cells to G-CSF (added at 0, 10 or 50 ng/ml) in in vitro cultures in the presence of human (hTERT Stroma).
Table 1.
Patient information for xenografts.