Table 1.
Patient demographic and clinical parameters.
Fig 1.
The distribution for MR-pro-ADM values within classes of clinical severity scores.
Upper panel: MR-pro-ADM distribution within CURB65 classes: statistically significant differences in MR-pro-AMD concentrations were found between CURB65 group 0 and 1 (p = 0.046); between CURB65 group 0 and 2 (p = 0.013); and between CURB65 group 0 and 3 (p = 0.0108). Lower panel; MR-pro-ADM distribution within classes PSI: statistically significant differences in MR-pro-AMD concentrations were found between PSI class 5 and 1 (p = 0.020), and between PSI class 5 and 3 (p = 0.044).
Fig 2.
MR-pro-ADM prediction in relation to study outcomes: AUC with a 95% CI for each predictor MR-pro-AMD, CURB65 and PSI, by main endpoint.
From upper left panel to lower right panel: overall death (CURB65: AUC [95% CI] = 0.824 [0.685–0.964], PSI: AUC [95% CI] = 0.766 [0.598–0.934], MRproADM: AUC [95% CI] = 0.837 [0.704–0.970]), death at 14 days (CURB65 –AUC [95% CI] = 0.910 [0.865–0.954], PSI:AUC [95% CI] = 0.811 [0.696–0.926], MRproADM: AUC [95% CI] = 0.824 [0.617–0.998]), non-invasive mechanical ventilation CURB65 –AUC [95% CI] = 0.855 [0.762–0.948], PSI: AUC [95% CI] = 0.872 [0.801–0.943], MRproADM: AUC [95% CI] = 0.858 [0.750–0.960]), endotracheal intubation (CURB65:AUC [95% CI] = 0.647 [0.418–0.875], PSI: AUC [95% CI] = 0.772 [0.648–0.896], MRproADM: AUC [95% CI] = 0.793[0.535–0.997]), total hospital stay>10 days (CURB65: AUC [95% CI] = 0.618 [0.502–0.735], PSI: AUC [95% CI] = 0.695 [0.582–0.807], MRproADM—AUC [95% CI] = 0.698 [0.580–0.817]), ED stay over 4 days (CURB65: AUC [95% CI] = 0.584 [0.466–0.702], PSI:AUC [95% CI] = 0.568 [0.444–0.691], MRproADM: AUC [95% CI] = 0.635 [0.512–0.758].
Fig 3.
Predictive performance of MR-pro-ADM in combination with PSI or CURB65 for overall death.