Fig 1.
A representative final report of the Dosimetry Toolkit.
(A) Illustration of the serial images of a patient with all regions of interest 4 h, 24 h, 48 h, 72 h and 168h p.i. (B) Normalised time-activity curves for all regions of interest. (C) Calculated residence times of all regions of interest.
Fig 2.
ROI/VOI comparison of all three imaging scenarios 24 h p.i. of the same patient.
The delineations of lungs, liver, kidneys, spleen, bladder and tumour (white, in the liver) are shown. (A) 2D presentation (summed coronal slice) of the 3D VOIs of the multi-SPECT-CT scenario. (B) Geometric mean image of the planar scenario with all ROIs. The small elongated delineations (*) next to the ROIs were used for background correction. (C) Geometric mean image of the WB scintigraphies with SPECT/CT based VOIs (hybrid scenario). Here, overlapping regions of interest were automatically removed (#) and corrected.
Table 1.
Patient whole body (WB) weight and determined organ masses.
The individual masses estimated with low-dose CT volumetry were used for weight adjustments in OLINDA/EXM software.
Table 2.
Residence times for the first therapy cycle (n = 16 patients) estimated by DTK using different imaging scenarios.
Table 3.
Dose per injected activity for the first therapy cycle (n = 16 patients), with respect to the different evaluation scenarios.
Table 4.
Dose per injected activity (DpA) and absorbed tumour doses of n = 23 liver tumour lesions of 16 patients for the first therapy cycle.