Fig 1.
Angiography sampled faster than cardiac rate.
Upper panel is human brain surface optical angiography with simultaneous visible recording via a beam splitter. The aneurysm is of the right middle cerebral artery, where F = frontal lobe, T = temporal lobe, and Ret = retractors. The lower panel is piglet ultrasound angiography via cranial window.
Fig 2.
Representative snapshot images and temporal data summaries for human subject h1 and piglet subject p1.
The yellow polygon in the images gives the region for motion tracking.
Fig 3.
Naive wavelet angiography and motion alias.
Apply wavelet transforms (⊙) to the pixel-wise time signals, filter for cardiac wavelet scale (s♡), and render by a brightness-hue color model that represents CF magnitude as brightness and phase as hue (right bottom inset). The double inset top right shows motion alias in the lengthwise bimodal phase.
Fig 4.
The top row is simulated pulse motion. The bottom row is simulated intraluminal contrast variation. The right column shows an image after naive CF wavelet filtering. The simulated pulse motion and intraluminal contrast variation can be combined.
Fig 5.
Cross-correlated wavelet angiography.
Top left, apply high temporal resolution wavelet (⊙) transformation to the pixel-wise time intensity curves. Bottom left, apply high frequency resolution wavelet transformation to the overall time intensity curve. Right side, cross-correlate these pixel-wise (⊗), filter for cardiac wavelet scale (s♡), inverse wavelet transform, then cine render.
Fig 6.
Wavelet angiography snapshots.
Fig 7.
Arterial and venous pixels are separated according to angiographic time of flight (ATOF). The derived time intensity curves are respectively consistent with predominantly arterial and venous temporal behavior.
Fig 8.
Arterial and venous time-indexed phase histograms with line scans.
Pixels classified by ATOF as arterial are in red and those as venous in blue. Relative histogram count is represented as brightness. The horizontal axis is time is depicted in heartbeats to facilitate human-piglet comparison. The vertical axis is phase ranging as [−π, π]. There is a consistent arteriovenous phase difference across the bolus passage.
Fig 9.
Arterial and venous motion-referenced phase histograms.
Pixels classified by ATOF as arterial are in red and those as venous in blue. Relative histogram count is represented as brightness. The horizontal axis is time is depicted in heartbeats to facilitate human-piglet comparison. The vertical axis is phase ranging as [−π, π]. Arterial versus venous phase appears approximately fixed in difference across the entire bolus passage. The circular phase histograms on the right are calculated by summing the time-indexed phase histograms on the left across time.