Fig 1.
Dependence of proton leak intensity (vLK) on protonmotive force (Δp).
State 4, state 3, rest, moderate work and heavy/severe work in skeletal muscle are indicated. vLK in all states is scaled for intact skeletal muscle. Simulations were made using the model version for intact skeletal muscle, as described in the text.
Fig 2.
Dependence of total oxygen consumption (),
related to proton leak and
related to ATP synthesis on ADP concentration.
Fig 3.
Dependence of total oxygen consumption (),
related to proton leak,
related to ATP synthesis, Δp, NADH (% of total NAD) and phenomenological ATP/O2 ratio on relative activity of ATP usage (relative rate constant, kUT, or its activation in relation to rest, AUT) in skeletal muscle for ‘standard’ proton leak activity.
Fig 4.
Dependence of total oxygen consumption (),
related to proton leak,
related to ATP synthesis, Δp, NADH (% of total NAD) and phenomenological ATP/O2 ratio on relative activity of ATP usage (relative rate constant, kUT, or its activation in relation to rest, AUT) in skeletal muscle for proton leak activity (rate constant) elevated twice in relation to the ‘standard’ value.
Fig 5.
Dependence of total oxygen consumption (),
related to proton leak,
related to ATP synthesis, Δp and NADH (% of total NAD) and phenomenological ATP/O2 ratio on relative activity of ATP usage (relative rate constant, kUT, or its activation in relation to rest, AUT) in skeletal muscle for proton leak activity (rate constant) set to zero (no proton leak).