Fig 1.
Funnel plot of publication bias.
Fig 2.
Flow diagram of the literature search.
Table 1.
Characteristics of multicentres, randomized, double-blind, placebo-controlled studies included in the meta-analysis.
Fig 3.
A risk of bias gragh, B risk of bias summary(“+”low risk;“?”, unclear risk;“-”,high risk).
Fig 4.
Forest plots of primary and secondary efficacy outcomes.
SD, standard deviation; CI, confidence interval; M-H, Mantel-Haenszel.
Fig 5.
Forest plots of discontinuation due to any reason, AEs, and lack of efficacy.
AEs, adverse effects; SD, standard deviation; CI, confidence interval; M-H, Mantel-Haenszel.
Table 2.
Meta-analysis of most frequent TEAEs.