Fig 1.
Schematic diagram of 3D-cMPR imaging at a constant depth from the chest wall and assessment.
Overall schematic diagram of the three-dimensional, curved high-resolution CT (3D-cHRCT) image at a constant depth from the chest wall and how it is used for assessment. Total area (TA), low attenuation area (LAA [< -950 HU]), and high attenuation area (%HAA) [> -500 HU]), which were obtained from 3D-cHRCT images, were computed on a workstation using a novel CAD program.
Fig 2.
A patient with clinical and radiological typical usual interstitial pneumonia.
A patient with clinical and radiological typical usual interstitial pneumonia. (a) Axial HRCT image and dashed line indicating 1-cm depth from the chest wall; multiple-view 3D-cHRCT images showing the 3D distribution of IP infiltrates; (b) left lateral view, (c) posterior view, (d) right lateral view.
Fig 3.
An example of HRCT axial view and 3D-cHRCT images of lung without IP.
An example of HRCT axial view and 3D-cHRCT images of lung without IP. (a) HRCT axial view and 3D-HRCT image of the left lung; (b) anterior view, (c) anterolateral view, (d) right lateral view, (e) posterolateral view, (f) posterior view. %HAA values of this case was 2.53%.
Fig 4.
An example of HRCT axial view and 3D-cHRCT images of lung with mild-IP.
An example of HRCT axial view and 3D-cHRCT images of lung with mild-IP. (a) HRCT axial view and 3D-HRCT image of the left lung; (b) anterior view, (c) anterolateral view, (d) right lateral view, (e) posterolateral view, (f) posterior view. %HAA values of this case was 6.74%.
Fig 5.
An example of HRCT axial view and 3D-cHRCT images of lung with moderate-IP.
An example of HRCT axial view and 3D-cHRCT images of lung with moderate-IP. (a) HRCT axial view and 3D-HRCT image of the left lung; (b) anterior view, (c) anterolateral view, (d) right lateral view, (e) posterolateral view, (f) posterior view. %HAA values of this case was 10.34%.
Table 1.
Patient characteristics.
Table 2.
CT visual assessment, values of %HAA and %LAA determined on 3D-cHRCT and PFT of patients classified according to visually assessed severity of interstitial pneumonia.
Fig 6.
3D scatter diagrams show the correlation between %DLCO and quantitative CT parameters.
3D scatter diagrams show the correlation between %DLCO and quantitative CT parameters. Both %HAA and %LAA are indicators of low diffusion capacity (standard partial regression coefficient [b*] = -0.453, P <0.001; b* = -0.447, P <0.001, respectively).
Table 3.
Multiple linear regression analysis of diffusion capacity and attenuation values from 3D-cHRCT images.
Table 4.
Attenuation values from 3D-cHRCT images of patients with normal and low %DLCO.
Table 5.
Multivariate logistic regression analysis for %DLCO <80%.