Table 1.
Summary of patient characteristics.
Fig 1.
Flow chart describing the study design as well as biopsy numbers in all groups.
Fig 2.
Distribution of Paneth cell AMP expression in relation to the location of biopsy harvesting in the gastrointestinal tract.
The relative expression of the Paneth cell AMPs HD5, HD6 and Reg3α was higher in the small intestine (n = 22) than in the stomach (n = 8) and large intestine (n = 104) in histologically normal biopsies (n = 134, p<0.02, Mann-Whitney-U-Test).
Fig 3.
Relative expression of Paneth cell AMPs correlates with severity of acute GI GvHD.
In the small intestine the relative expression of HD5 (p = 0.004), HD6 (p = 0.006) and Reg3α (p = 0.012) was significantly decreased (Mann-Whitney-U-Test) in case of severe acute GvHD (stage 2–4) (3A). Patients with acute intestinal GvHD stages 2–4 showed an increase in expression of HD5 (p<0.001), HD6 (p<0.001) and Reg3α (p = 0.002) in the large intestine (Mann-Whitney-U-Test) (3B).