Table 1.
Sample characteristics of the study population.
Fig 1.
Graphical rendering of tractographies in a representative subject.
Tractographies of the left-hand side of the dorsal cingulum (A), the ventral cingulum (B), the superior longitudinal fasciculus (SLF; C), and the corticospinal tract (CST; D) segmented from a whole-brain tractography and superimposed on a mid-sagittal FA map.
Fig 2.
FLAIR images of two different representative subjects with different WMH load.
Subject A represents lower WMH load (i.e. a WMH volume ≤ 0.5% of the intracranial volume that corresponded approximately to Fazekas grade 0–1) and subject B higher WMH load (i.e. a WMH volume ≥ 1% of the intracranial volume that corresponded approximately to Fazekas grade 2–3), with arrows indicating example regions with WMH.
Table 2.
Comparison of MD and FA between the matched subgroups of cognitively healthy elderly with lowera and higherb WMH load, respectively, using a two-tailed Student’s t-test.
Table 3.
Multivariate linear regression analyses of MD and FA in the dorsal and ventral cingulum, the SLF, and the CST in cognitively healthy elderly (n = 132) and prodromal AD subjects (n = 83) unadjusted (model 1) and adjusted (model 2) for WMH volume, respectively.
Table 4.
Effect size of group mean expressed as Cohen’s d and group size (n, patient group + control group) for WMH in the present study and various pathological conditions previously studied using DTI.