Fig 1.
Diffuse and strong LAT1 expression in a small cell glioblastoma (a) and in a metastasis of ovary adenocarcinoma (b). Weak LAT1 expression in a glioblastoma (c) and in a metastasis of lung adenocarcinoma (d). Note LAT1 expression in endothelial cells (c).
Table 1.
Histological characteristics and expression of LAT1 in brain tumours.
Fig 2.
Correlation between LAT1 scores and [18F] FDOPA standardized uptake values.
a) correlation between LAT1 scores and SUVmax of tumours. b) correlation between LAT1 scores and ratio SUVmax T/S.
Fig 3.
Illustration of LAT1 score and [18F] FDOPA PET in four cases: MRI (a,d,g,j), [18F] FDOPA-PET images fused with MRI (b, e, h, k) and LAT1 scores (c, f, i, l) of four cases are presented to illustrate the results. Case 20 (a, b, c) corresponding to a metastasis from breast carcinoma displayed a high SUVmax (6.18), a ratio SUVmax T/S of 1.24 and a high score of LAT1 expression (285). Case 28 (d, e, f) corresponding to a glioblastoma showed a high SUVmax (7.48), a ratio SUVmax T/S of 1.53 and a high LAT1 score (200). Case 8 (g, h, i) corresponding to a glioblastoma showed a high SUVmax (11.21), a ratio SUVmax T/S of 2.18 and a low LAT1 score (50). Case 22 (j, k, l) corresponding to a glioblastoma showed a high SUVmax (9.3), a ratio SUVmax T/S of 2.47 and a low LAT1 score (40).
Table 2.
Relation between intervals from treatment to PET scan and parameters of [18F] FDOPA uptake.