Fig 1.
Schematic overview of the latent variable model for the association between cerebral serotonin 4 receptor (5-HT4R) binding potential (BPND) and NEO personality traits.
A separate model was determined for each of the five NEO personality traits: Neuroticism, Extroversion, Openness, Agreeableness and Conscientiousness. The circle represents the latent 5-HT4R variable (LVu). Light gray boxes indicate observed predictors and the dark gray boxes, predicted by the latent variable, represent observed log-transformed regional 5-HT4R BPND and NEO personality trait. Age, gender, and BDNF val66met genotype all map directly onto the latent variable (LVu). Age and sex also predict the personality trait and 5-HTTLPR genotype predicts neocortex regional BPND only. Not shown in the model are two observed predictors 1) scanner type (GE-Advance vs. HRRT PET scanner) and 2) weight adjusted injected mass, which map directly onto each regional BPND. The hatched line between amygdala and hippocampus reflects additional shared correlation. Circular hatched lines denote parameters estimated with error.
Table 1.
Descriptive data.
Table 2.
NEO personality and regional 5-HT4R binding potential.
Table 3.
Latent variable model path analyses.