Table 1.
Patient demographics and clinical data.
Table 2.
Electrophysiological test results.
Fig 1.
Lumbosacral plexus with dorsal root ganglia.
Images were obtained from maximum intensity projections of spinal cord and lumbosacral plexus images acquired by a SPACE STIR sequence. Left column shows images from a healthy control with small, normal sized dorsal root ganglia. Right column shows images from a patient after exposure to a cumulative dose of 510 mg/m2 OXA. Insets in lower line show magnifications of L4 and L5 DRG. Nerve roots filled with cerebrospinal fluid contact the DRG, whose fibers then continue into the spinal nerve roots.
Fig 2.
Nerve appearance in T2-w at thigh and calf level.
Exemplary OXA-treated patients without apparent peripheral nerve alterations (patient #2, left column) and with apparent minor nerve alterations (patient #7, right column). The sciatic nerves on the right exhibit slightly increased T2-w signal and caliber thickening of individual fascicles (arrow). Overall, peripheral nerve changes are mild.
Fig 3.
DTI nerve appearance at thigh level.
The six images demonstrate DTI images of an exemplary OXA-treated patient. B0 maps were used for nerve identification and segmentation. MD, AD, and RD show parameter maps. FA maps are shown in grey-scale, and additionally color-maps for indication of preferential diffusion direction.
Fig 4.
Boxplots of quantitative results.
[A] shows values for DRG in OXA-treated patients (grey boxes) vs. controls (white boxes). [B] shows normalized T2 values for the sciatic nerve at mid-thigh level. [C] gives values for the sciatic nerve caliber at mid-thigh level. [D] shows values for DTI parameters AD, RD, and MD while [E] depicts resulting FA values. Boxplots give median, 25% and 75% quartile values. Whiskers indicate 5% and 95% percentile.