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Table 1.

Main non-collagenous extracellular matrix proteins present in tooth hard tissues.

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Table 2.

Non-synonymous polymorphisms present in tooth proteins of Neanderthal and Denisova hominins.

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Fig 1.

Geographical distribution of the dental protein variants common to archaic hominins in living people.

The colored amino acid corresponds to the archaic variant. Yellow corresponds to the major allele; blue and green correspond to minor alleles with a proportion out of 1 and 0.1, respectively. The maps were generated in the Geography of Genetic Variants Browser (http://popgen.uchicago.edu/ggv/) [50].

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Fig 1 Expand

Fig 2.

Geographical distribution of the dental protein variants specific to Neanderthals in living people.

The colored amino acid corresponds to the archaic variant. Yellow corresponds to the major allele, green, purple and brown correspond to minor alleles with a proportion out of 0.1, 0.001 and 0.0001, respectively. The maps were generated in the Geography of Genetic Variants Browser (http://popgen.uchicago.edu/ggv/) [50].

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Fig 2 Expand

Fig 3.

Geographical distribution of dental protein variants A: specific to Denisova, B: at least present in Denisova in living people.

The colored amino acid correspond to the archaic variant. Yellow corresponds to the major allele, blue, green, red and purple corresponds to minor alleles with a proportion out of 1, 0.1, 0.01 and 0.001, respectively. The maps were generated in the Geography of Genetic Variants Browser (http://popgen.uchicago.edu/ggv/) [50].

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Fig 3 Expand

Fig 4.

Localization of tooth protein genes in two clusters on chromosome 4.

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Fig 4 Expand