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Fig 1.

Study selection flow chart.

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Table 1.

Characteristics of the included studies.

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Fig 2.

Forest plots to compare the combination therapy with the monotherapy: Cognitive functions.

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Fig 3.

Forest plots to compare the combination therapy with the monotherapy: BPSD.

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Fig 4.

Forest plots to compare the combination therapy with the monotherapy: global functions.

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Table 2.

Subgroup analysis results of study outcomes.

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Table 2 Expand

Table 3.

Adverse event and risk ratio of the combination treatment primary outcomes in Alzheimer disease (endpoint).

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Table 3 Expand