Table 1.
Demographic and clinical characteristics of the RISC cohort*.
Fig 1.
Scatterplot of diagnostic protein biomarkers.
Circulating levels of top-ranked diagnostic biomarkers in IGT subjects (case, left) compared to healthy controls (right).
Table 2.
Diagnostic predictors of β-cell function*.
Fig 2.
Scatterplot of prognostic protein biomarkers.
Circulating levels of top-ranked prognostic biomarkers in IGT subjects (case, left) compared to healthy controls (right).
Table 3.
Prognostic predictors of β-cell function*.
Fig 3.
Venn diagram of prognostic and diagnostic protein predictors based on the univariate analysis with p<0.05.
Twelve proteins were identified as differentially expressed at both time-points; 48 proteins were only predictive at baseline; and 29 only at follow-up. Proteins in bold were among top 20 in both prognostic and diagnostic lists.
Fig 4.
Venn diagram of prognostic and diagnostic miRNA predictors based on the univariate analysis with p<0.05.
11 miRNAs were identified as differentially expressed at both time-points; 6 miRNAs were predictive of ß-cell glucose sensitivity at baseline only; and 16 only at follow-up.