Table 1.
Patients characteristics.
Table 2.
The sensitivity, specificity, PPV, NPV, and overall accuracy of gastric distention US and DCUS.
Fig 1.
A 65-year-old man with a gastric signet-ring cell carcinoma.
a: Oral contrast agent ultrasound detected an irregular mass in gastric fundus. b: DCUS showed a homogeneous hyper-enhancement tumor. c: Many signet-ring cells (hematoxylin and eosin, × 200) in microscopic field. d: Time-intensity curve depicted the lesion (red line) have faster AT, higher PI and AUC than surrounding normal tissue (yellow).
Table 3.
CEUS parameters of different gastric lesions and compare with normal tissue.
Fig 2.
A 43-year-old woman with a gastrointestinal stromal tumor.
a: Conventional trans-abdominal ultrasound with oral contrast agent showed a lobulated heterogeneous hypoechoic lesion (calipers) located in antrum of stomach, a hyper-echoic calcification plaque could be detected inside of the tumor. b: DCUS showed a ring-like hyper-enhancement (arrow) and heterogeneous hyper-enhanced inside of the lesion. c,d: Microscopic certificated the calcification in GIST (arrow in c)and fascicular proliferation of spindle-shaped cells.(d)(hematoxylin and eosin, × 200). e: Time-intensity curve depicted the lesion (red line) have higher PI and faster AT, TTP than surrounding tissue (yellow), final pathology result classified this GIST into high-risk category.
Fig 3.
A 59-year-old woman with an inflammatory mass.
a: Gastro-endoscope detected a bump with intact overlying mucosa protruding into the cavity. b: Conventional trans-abdominal ultrasound with oral contrast agent showed a well-defined hypoechoic lesion (star), with an intact mucosa. c: multiple vessels were visible on the color Doppler. d: DCUS showed a homogeneous hyper-enhanced mass in the antrum. e: Time-intensity curve depicted the lesion (red line) have higher PI than surrounding normal tissue (yellow).
Fig 4.
A 65-year-old man with a polypoid adenoma.
a: Conventional trans-abdominal ultrasound with oral contrast agent showed an irregular hypoechoic lesion (arrow) located in antrum. b: Multiple flow signals were visible on the color Doppler. c: DCUS showed homogeneous hyper-enhanced mass connected with gastric wall by a pedicle (arrow). d: Time-intensity curve depicted the lesion (red line) have higher PI than surrounding normal tissue (yellow).
Table 4.
Comparison of CEUS parameters between the different gastric lesions (P value).