Fig 1.
Geographic MAF distribution of 501 PGx variants found in the 1000 Genomes project populations.
Fig 2.
Chromosomal location and functional consequence distribution per chromosome of the PGx variants.
The accompanied table shows the PGx variants and genes located in each chromosome.
Fig 3.
Distribution of common (MAF≥0.1) possibly damaging (left) and benign (right) PGx variants across 1kG populations.
These are African/AFR (GWD, MSL, ESN, YRI, LWK, ACB, ASW), Ad Mixed America/AMR (MXL, CLM, PEL, PUR), East Asian/EAS (CHS, KHV, CHB, JPT, CDX), European/EUR (TSI, IBS, GBR, CEU, FIN), South Asian/SAS (PJL, STU, ITU, BEB, GIH) ancestral groups.
Fig 4.
Minor Allele Frequency heatmap for 79 PGx variants that are common (MAF> = 0.1) and rare (MAF< = 0.005) in at least one 1kG population.
Fig 5.
Minor Allele frequency distribution for the ten most differentiated PGx variants among 1kG ancestral groups.
Fig 6.
Genomic annotation plot combined with PGx variant MAFs in 1kG populations.
Fig 7.
Individual haplotypes that did not match to any known haplotype per gene.
Colours represent the five ancestral groups. Grey fills indicate haplotype matches.
Table 1.
Matching distribution of individuals per ancestry group for the haplotypes with the highest variability and significant percentage match.
Fig 8.
Haplotype Frequency (HAF) heatmap for 53 PGx haplotype that are common (HAF> = 0.1) and rare (HAF< = 0.005) in at least one 1kG population.
Fig 9.
Distribution of three phenotypes (WT/WT-green, WT/V-orange, V/V-red) for 5 highly covered genes with high phenotypic difference among 1kG populations.