Fig 1.
Flow chart of the study.
Fig 2.
Typical QT and T-wave changes (A) in a subject with a pronounced sotalol-induced IKr inhibition indicated by a notch and (B) in a subject with minimal sotalol-induced IKr inhibition.
The PC1 values and distribution of discovery cohort are shown. PC1 is issued from principal component analysis of ΔQTc, ΔTpTe and ΔTAmp. “Notcher” subjects are represented in red and “non notcher” in black.
Table 1.
Demographic and baseline ECG characteristics of patients who received sotalol.
Fig 3.
Correlations between ΔQTcF (%), ΔTpTe (%) and ΔTAmp (%) in the discovery (Adisc-Cdisc, n = 489) and replication cohort (Arep-Crep, n = 495).
“Notcher” subjects are represented in red.
Table 2.
ECG characteristics of patients 3 hours post sotalol administration.
Table 3.
Correlations (r) between ΔTAmp, ΔTpTe, ΔQTcF and results of principal component (PC) analysis in discovery (n = 489, in bold) and replication (n = 495, highlighted in italic) cohort.
Table 4.
Electrocardiographic findings of patients who presented or did not present with notching 3 hours post sotalol administration in the discovery and replication cohort.
Table 5.
SNPs significantly associated at p<5*10−8 and imputation r2>0.4 with an ECG phenotype in the discovery imputation association analysis and their validation in an independent sample.