Fig 1.
Prisma diagram of search strategy.
Table 1.
Characteristics of randomized controlled trials published in the three highest-impact journals between January 1, 2010 and December 31, 2015.
Table 2.
Published RCTs that were registered before or during trial completion and have major discrepancies with their trial registries, and the effect of these discrepancies on the statistical significance of published outcomes, by funding source.
Table 3.
Published RCTs that were registered before or during trial completion and have major discrepancies with their trial registries and the effect of these discrepancies on the statistical significance of published outcomes, by funding source.
Table 4.
Year-by-year frequency of major discrepancies between published and registered outcomes in RCTs registered before or during patient enrollment (n = 181), and the effect of these discrepancies on the statistical significance of published outcomes, by year.