Table 1.
Demographic and clinical characteristics of enrolled subjects with PD and MSA-P.
Fig 1.
Comparison of COMPASS 31 scores among the patients with PD and MSA-P.
The MSA-P patient group had higher total COMPASS 31 scores and higher sub-scores in the orthostatic intolerance, gastrointestinal, and bladder domains compared with PD patients. The error bars represent the standard error of mean. COMPASS 31, composite autonomic symptom scale 31 questionnaire; PD, Parkinson’s disease; MSA-P, multiple system atrophy with predominant parkinsonism. *p-value < 0.05.
Table 2.
Results of the evaluation of autonomic function between PD and MSA-P patients using the COMPASS 31 and objective autonomic function test.
Fig 2.
ROC curve for COMPASS 31 total score diagnostic performance.
With 13.25 as the cut-off score for differential diagnosis of MSA-P from PD, the total COMPASS 31 score demonstrated high sensitivity (92.6%) and moderate specificity (51.2%) with an area under the curve of 0.765. ROC, receiver operating characteristic; COMPASS 31, composite autonomic symptom scale 31 questionnaire; MSA-P, multiple system atrophy with predominant parkinsonism; PD, Parkinson’s disease.