Table 1.
Main demographic and clinical characteristics of the patients.
Fig 1.
Anatomical localization of cerebellar ROIs for tractography of MCP and SCP.
Cerebellar ROIs manually drawn on the FA map images for MCP (A) and SCP (B) tracking. For MCP, the coronal seed ROIs (in red) are illustrated. In the axial slice, cerebellar seed and waypoint ROIs are indicated by the white arrows. For the left SCP the seed region (coronal slice) and the endpoint ROI (axial slice) are illustrated (white arrows). Note that for the right SCP the same ROIs were used swapping right and left hemispheres (ROIs not shown).
Table 2.
Characteristics of the cerebellar lesion in studied patients.
Fig 2.
Lesion reconstruction and distribution in patients.
Each individual lesion is presented and superimposed on coronal (= y), sagittal (= x) and axial (= z) slices of the SUIT atlas template (Diedrichsen et al., 2009) after spatial normalization. Patients codes as in Tables 1 and 2. The bottom left of the figure shows the SUIT atlas.
Table 3.
Statistics of cerebellar white-matter voxel-wise comparisons for each patients’ group.
Fig 3.
DTI-based tractography of middle and superior cerebellar peduncles.
DTI-based tractography of the average tract of MCP (red), L-SCP (blue) and R-SCP (green) with voxels belonging to at least 50% of the subjects.
Fig 4.
Voxel-wise analysis of white matter tracts.
Regions showing altered Radial Diffusivity (A), Mean Diffusivity (B) and Fractional anisotropy (C) in patients compared to controls. The regions in the middle cerebellar peduncle are shown in light blue; the regions in superior cerebellar peduncle are shown in red. Axial diffusivity was not significantly affected (data not shown).
Table 4.
Statistics of whole brain voxel-wise comparisons for each patients’ group (Cb-L<HS).
Fig 5.
Between groups voxel-based comparison of cerebral GM density.
Regions showing patterns of reduced regional GM in patients compared to HS in both contralateral and ipsilateral cerebral cortex.