Table 1.
Fig 1.
*Exclusion criteria: (1) not a human study, (2) not published in English, (3) meta-analysis, review, or letter to the editor, (4) clinical trial, (5) not a genetic association study, (6) not a mucositis-related phenotype study, or (7) duplicate from another search.
Table 2.
Summary of literature search.
Fig 2.
Most significant network (p = 10−22) generated by IPA core analysis for mucositis, using 27 focus genes.
Green nodes: focus genes with fewer than 15 connections; red nodes: non-focus molecules with at least 15 connections; yellow nodes: focus genes with at least 15 connections. Dashed and solid lines represent indirect and direct interactions, respectively.
Table 3.
Molecules with ≥ 15 connections (hubs*) and focus genes with < 15 connections in the network, ranked by number of connections.
Table 4.
Top canonical pathways (B-H p-valueƗ < 10−5) discovered by IPA core analysis*.
Table 5.
Top 25 diseases and functions discovered by IPA core analysis of focus genes*.
Table 6.
Results of the genetic association analysis for oral mucositis in 885 head and neck cancer patients (186 oral mucositis cases and 699 controls), using the IPA-derived hubs (most interconnected molecules) as the candidate molecules.