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Fig 1.

Proposed framework.

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Fig 1 Expand

Table 1.

Zsyntax inference rules.

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Table 1 Expand

Table 2.

Definitions of Zsyntax formalization.

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Table 2 Expand

Fig 2.

Graphical depiction of formalization of Zsyntax.

(a) Elimination of the Z-Conjunction Rule (zsyn_conjun_elimin) (b) Introduction of Z-Conjunction (zsyn_conjun_intro) (c) Reactants Deletion (zsyn_delet) (d) EVF Matching (zsyn_EVF).

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Fig 2 Expand

Table 3.

Formal verification of Zsyntax properties.

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Table 3 Expand

Table 4.

Definitions of reaction kinetics formalization.

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Table 4 Expand

Fig 3.

Reaction schemes.

(a) Irreversible Consecutive Reactions (b) Consecutive Reactions with the Second Step being Reversible (c) Consecutive Reactions with the First Step as a Reversible Reaction (d) Consecutive Reactions with a Reversible Step.

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Fig 3 Expand

Table 5.

Formal models of generic reaction schemes.

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Table 5 Expand

Table 6.

Formal verification of reaction kinetics properties.

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Table 6 Expand

Fig 4.

Case studies.

(a) Reaction Representing the TP53 Phosphorylation (b) Model for the Tumor Growth [20].

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Fig 4 Expand

Fig 5.

Case studies.

(a) Reaction Representing the death of CSC (b) Another Model for the Growth of Tumor Cell.

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Fig 5 Expand