Table 1.
Main characteristics of the patients included in this study.
Fig 1.
Distribution of patients with RA positive for the different autoantibodies.
A proportional Venn diagram representing percentages (%) of patients in each of the antibody strata: anti-CCP positive in the lower left oval, RF positive in the lower right oval and anti-CarP positive in the upper one. Percentage of triple negatives is shown outside the Venn diagram in the upper left corner.
Fig 2.
Kaplan-Meier survival curves of all patients with RA stratified by demographic factors.
(A) Stratified by age in relation with the median age at the time of recruitment (red ≥ 69 years, blue < 69 years); (B) stratified by smoking habit (red = ever smoker, blue = never smoker), and (C) stratified by gender (red = men, blue = women). Dots = deaths, crosses = censored data.
Fig 3.
Kaplan-Meier survival curves of all patients with RA stratified by the status of the RA specific antibodies.
(A) anti-CarP antibodies, (B) RF, and (C) anti-CCP antibodies. Red = antibody positive, blue = antibody negative, dots = deaths, crosses = censored data. Note that these are unadjusted analyses.
Fig 4.
Comparison of the HR obtained by Cox proportional analysis of the three RA autoantibodies.
(A) The three antibodies, RF, anti-CCP and anti-CarP, considered each of them separately; and (B) the three antibodies considered conditional on the other two (indicated by the apostrophe, ‘, over them). Error bars correspond to the 95% CI. The asterisks, *, denote significantly increased HR.
Fig 5.
Conditional analysis of the HR observed with the number of autoantibodies.
The HR for the number of antibodies (# Ab) obtained in Cox proportional analysis was considered either on itself (to the left of the dotted vertical line) or conditional on the presence of each of the three specific autoantibodies (to the right of the dotted vertical line). The asterisks, *, denote significantly increased HR.