Fig 1.
A photographic example of fundus photography and swept-source optical coherence tomography in an eye with acute anterior uveitis associated with human leukocyte antigen (HLA)-B27, covering a 12 (horizontal) × 9 (vertical)-mm area (box in left).
Automated measurement of choroidal thickness by automated segmentation, which demarcates the outer border of the retinal pigment epithelium and the inner border of chorioscleral interface (indicated by lines), was performed using software provided by the manufacturer. A choroidal thickness map (upper right) was generated, and subfoveal choroidal thickness and parafoveal choroidal thicknesses were used for our analyses. Peripapillary thicknesses were also measured by automated segmentation and thickness mapping (lower), and the thicknesses on 4 quadrants (lower right) were used for our analyses. N = nasal; S = superior; T = temporal; I = inferior.
Table 1.
Demographic data and clinical characteristics of included patients.
Data are presented as number of patients (%) or mean ± standard deviation.
Fig 2.
Swept-source optical coherence tomography (SS-OCT) B-scan images in three representative patients with unilateral, acute, anterior uveitis.
Compared to the fellow eyes (right), the eyes with acute anterior uveitis (left) show choroidal thickening of the macular area, which can be also determined by numerical values of choroidal thicknesses of the thickness maps (right side of each figure). Choroidal thickness decreased after topical and/or systemic corticosteroid therapy in the eyes with uveitis. In the fellow eyes, however, there were no significant changes in choroidal thickness before and after the treatment. The numbers within parentheses indicate the grades of anterior chamber inflammation.
Fig 3.
En face choroidal imaging in an eye with acute anterior uveitis and the fellow eye.
The choriocapillaris or Sattler’s layer shows no remarkable change between uveitic and fellow eyes or before and after the treatment in the uveitic eye. However, the Haller’s layer in the eye with active uveitis shows dilation of the large choroidal vessels on the macular area at baseline (Box 1) compared to images obtained after treatment (Box 2) or fellow eye, which is more remarkable in magnified images on the macular area (lower).
Fig 4.
Comparison of macular and peripapillary choroidal thicknesses between eyes with acute anterior uveitis and the fellow eyes.
There are significant differences in subfoveal and parafoveal choroidal thicknesses between the uveitic and fellow eyes. Asterisk (*) indicates statistical significance (P <0.05).
Fig 5.
Comparison of macular and peripapillary choroidal thicknesses before and after treatment of anterior uveitis.
Subfoveal and parafoveal choroidal thickness thinned significantly following treatment (all P <0.05). Peripapillary choroidal thicknesses show significant difference only in nasal and temporal quadrants. Asterisk (*) indicates statistical significance (P <0.05).